Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

Fig. 3

Intracellular metabolism of azacytidine and decitabine. Azacytidine (5-AZA-CR) and decitabine (5-AZA-dCR) are modified in a 3-step phosphorylation process by different metabolic pathways. 5-AZA-CTP/5-AZA-dCTP is incorporated into RNA or DNA by RNA/DNA polymerases, respectively. CDA can deaminate azacytidine and decitabine to inactive aza-uradine nucleosides. CDA cytidine deaminase, 5-AZA-CR 5-azacitidine, 5-AZA-CMP 5-azacitidine monophosphate, 5-AZA-CDP 5-azacitidine diphosphate, 5-AZA-CTP 5-azacitidine triphosphate, 5-AZA-U aza-uridine nucleosides, 5-AZA-dCR 5-aza-2’-deoxycytidine, 5-AZA-dCMP 5-aza-2’-deoxycytidine monophosphate, 5-AZA-dCDP 5-aza-2’-deoxycytidine diphosphate, 5-AZA-dCTP 5-aza-2’-deoxycytidine triphosphate, 5-AZA-dU deoxyuridine

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