Fig. 2
From: Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
The epigenetic states of ageing and rejuvenation. Ageing and rejuvenation can be affected by intrinsic epigenetic alterations and genetic instability, like DNA methylation and chromatin remodeling. Moreover, many extrinsic factors, like microenvironmental cues, intercellular communication, and systemic factors, can also impact the epigenetic states of ageing and rejuvenation. miRNAs microRNAs, lncRNAs long noncoding RNAs, ECM extracellular matrix. Created with BioRender.com
