Fig. 4
From: Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
Schematic overview of strategies for cell rejuvenation. Various strategies have been developed for cell rejuvenation that leverage intrinsic and extrinsic factors, including epigenetic reprogramming, genetic enhancement, autophagy modulation, and metabolic manipulation. Furthermore, small molecules, growth factors and cytokines, blood factors, iPSC technology, clearance of senescent cells and SASP, microenvironment regulation, and circadian clock modulation can also exert great influences on cell rejuvenation. iPSCs induced pluripotent stem cells, SASP senescence-associated secretory phenotype. Created with BioRender.com
