Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Emerging phagocytosis checkpoints in cancer immunotherapy

Fig. 6The alternative text for this image may have been generated using AI.

CD47-SIRPα pathway. a CD47 expressed on tumor cells interacts with SIRPα expressed on macrophages and other phagocytes to avoid immune surveillance. b Targeting CD47 or blocking the CD47-SIRPα axis interrupts their interaction and allows macrophages to phagocyte tumor cells. c CD47 expressed on hematopoietic cells or red blood cells interacts with SIRPα expressed on macrophages and other phagocytes to avoid phagocytosis. d Targeting CD47 or interrupting the CD47-SIRPα axis allows macrophages to phagocyte hematopoietic cells and thus brings the side effects such as anemia

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