Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Oncolytic virotherapy: basic principles, recent advances and future directions

Fig. 5

Different strategies of OV engineering for anti-angiogenesis and the possible induced phenotype of TME. ① Some OVs have been modified to attack tumor-associated endothelial cells, while the immunosuppressive TME provide a perfect niche for “cold” tumor development. ② Normalizing the tumor vasculature may promote immune cell infiltration and OV diffusion, giving rise to “hot” tumors. Created with BioRender.com

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