Fig. 2
From: Cdc2-like kinases: structure, biological function and therapeutic targets for diseases
Biology function of CLKs. CLKs participate in biological processes by modulating splicing and non-splicing functions. CLKs are activated, phosphorylated or regulated by c-Myc, AKT or 14–3–3τ, or negatively regulated by miRNAs. CLKs affect their downstream effectors by phosphorylating serine, threonine, or tyrosine residues to activate cellular splicing and non-splicing processes. Alternative splicing of certain genes is increased in response to protein phosphorylation by CLKs. Targets of CLKs include SR proteins, SPF45, and/or U1–70K or modulated RBFOX2. Consequently, different protein isoforms that function in multiple cellular processes are generated. CLKs promote cytokinesis, increase c-myc activity, and suppress fatty acid metabolism by phosphorylating downstream Aurora B, USP13, and PGC-1α. The activation of Wnt/β-catenin and Hippo signaling by increased expression of Wnt 3a or YAP further highlights the importance of CLKs in non-splicing processes. The figure was generated using Figdraw (www.figdraw.com)
