Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Fig. 5

Expression status and clinical outcomes associated with CLKs transcript levels in different tumor types. a RNA-seq data of CLKs expression in tumor and normal tissues were obtained from the TCGA database (https://portal.gdc.cancer.gov/). The Kruskal-Wallis test was used to assess statistical significance. b Raw counts of clinical survival information of CLKs were obtained from The TCGA dataset (https://portal.gdc.cancer.gov/). The KM survival analysis with log-rank test was also used to compare the survival differences between the above two groups. For Kaplan–Meier curves, p values, and hazard ratio (HR) with 95% confidence interval (CI) were generated by log-rank tests and univariate Cox proportional hazards regression. *, ** and *** represented p < 0.05, p < 0.01 and p < 0.001, separately. p < 0.05 was considered statistically significant

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