Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Inside-out assembly of viral antigens for the enhanced vaccination

Fig. 1

Schematic illustration of the inside-out assembly of the viral antigens. Compared with the natural dissemination (iMASE, left), the reversed delivery (rMASE, right) allowed for the prior encountering of NP to the immune surveillance, as hidden caterpillars (pathogens) were forced to expose their “soft spot” to the predators (immune systems), provoking IFN-I secretion in advance. Along with the delivered surface antigen, rMASE promoted the innate immune response for enhanced antibody secretion and antigen-specific T cell immune response against viral challenge

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