Table 1 Reported GPCR structures

From: G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Class

Receptors

Total number

PDB ID (receptor alone)

PDB ID (G protein coupled receptor)

A

ADRB3

1

 

7DH5

AGTR1

6

6OS0, 6OS1, 6OS2, 6DO1, 4ZUD, 4YAY

 

AGTR2

7

7JNI, 7C6A, 6JOD, 5XJM, 5UNH, 5UNG, 5UNM

 

HTR1A

3

 

7E2X, 7E2Y, 7E2Z

HTR1B

5

7C61, 5V54, 4IAR, 4IAQ

6G79

HTR1D

1

 

7E32

HTR1E

1

 

7E33

HTR1F

1

 

7EXD

HTR2A

13

7WC4, 7WC5, 7WC6, 7WC7, 7WC8, 7WC9, 7VOD, 7VOE, 6WGT, 6WH4, 6A94, 6A93

6WHA

HTR2B

8

6DRY, 6DS0, 6DRZ, 6DRX, 5TUD, 5TVN, 4NC3, 4IB4

 

HTR2C

2

6BQG, 6BQH

 

ACM1

6

6ZFZ, 6ZG9, 6ZG4, 6WJC, 5CXV

6OIJ

ACM2

10

5ZKB, 5ZKC, 5ZK3, 5ZK8, 5YC8, 4MQT, 4MQS, 3UON

6U1N, 6OIK

ACM3

5

5ZHP, 4U14, 4U15, 4U16, 4DAJ

 

ACM4

2

6KP6, 5DSG

 

ACM5

1

6OL9

 

APJ

2

6KNM, 5VBL

 

BKRB1

1

 

7EIB

BKRB2

1

 

7F2O

C5AR1

3

6C1Q, 6C1R, 5O9H

 

CCKAR

8

7F8X, 7F8U, 7F8Y

7EZM, 7EZH, 7EZK, 7MBX, 7MBY

CCR1

3

 

7VLA, 7VL8, 7VL9

CCR2

3

 

6GPS, 6GPX, 5T1A

CCR5

11

7F1T, 6MET, 6MEO, 6AKY, 6AKX, 5UIW, 4MBS

7F1Q, 7F1R, 7F1S, 7O7F

CCR6

1

 

6WWZ

CCR7

1

6QZH

 

CCR9

1

5LWE

 

CNR1

8

7V3Z, 6KQI, 5XRA, 5XR8, 5U09, 5TGZ

6KPG, 6N4B

CNR2

4

6KPC, 5ZTY

6KPF, 6PT0

CXCR2

3

6LFL

6LFM, 6LFO

CXC-R4

6

4RWS, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9

 

DRD1

11

 

7JOZ, 7CKW, 7CKX, 7CKY, 7CKZ, 7CRH, 7LJC, 7LJD, 7JV5, 7JVP, 7JVQ

DRD2

5

7DFP, 6LUQ, 6CM4

7JVR, 6VMS

DRD3

3

3PBL

7CMV, 7CMU

DRD4

3

6IQL, 5WIV, 5WIU

 

EDNRB

8

6LRY, 6K1Q, 6IGL, 6IGK, 5XPR, 5X93, 5GLH, 5GLI

 

FFAR1

4

5KW2, 5TZY, 5TZR, 4PHU

 

FPR1

2

 

7WVU, 7T6T

FPR2

9

6LW5

7WVV, 7WVX, 7WVW, 7WVY, 7T6V, 7T6S, 7T6U, 6OMM

GALR1

1

 

7WQ3

GALR2

1

 

7WQ4

CCKBR

2

 

7F8V, 7F8W

GHSR

7

7F83, 6KO5

7W2Z, 7NA7, 7NA8, 7F9Y, 7F9Z

GNRHR

1

7BR3

 

GPBAR1

3

 

7CFM,7CFN, 7BW0

HRH1

2

3RZE

7DFL

LPAR1

6

4Z34, 4Z35, 4Z36

7TD0, 7TD1, 7TD2

LSHR

4

7FIJ

7FIG, 7FII, 7FIH

LT4R1

2

7K15

7VKT

MC4R

8

6W25

7PIV, 7PIU, 7F53, 7F54, 7F55, 7F58, 7AUE

MSHR

4

 

7F4D, 7F4H, 7F4I, 7F4I

MTNR1A

8

6PS8, 6ME2, 6ME3, 6ME4, 6ME5

7VGY, 7VGZ, 7DB6

MTNR1B

5

6ME6, 6ME7, 6ME8, 6ME9

7VH0

NK1R

11

6J20, 6J21, 6HLP, 6HLL, 6HLO, 6E59

7P00, 7P02, 7RMI, 7RMG, 7RMH

NPY1R

3

5ZBH, 5ZBQ

7VGX

NPY2R

1

7DDZ

 

NTSR1

24

6YVR, 6Z4Q, 6Z4S, 6Z4V, 6Z66, 6Z8N, etc

7L0P, 7L0Q, 7L0R, 7L0S, 6UP7, 6PWC, 6OSA, 6OS9

OPRD

6

6PT2, 6PT3, 4RWD, 4RWA, 4N6H, 4EJ4

 

OPRK

3

6VI4, 6B73, 4DJH

 

OPRM

7

5C1M, 4DKL

7U2L, 7SBF, 7SCG, 6DDF, 6DDE

OPRL1

3

5DHG, 5DHH, 4EA3

 

HCRTR1

14

6V9S, 6TOT, 6TOS, 6TOD, 6TQ4, 6TP4, etc

 

HCRTR2

8

6TPG, 6TPJ, 6TPN, 5WS3, 5WQC, 4S0V

7L1U, 7L1V

OXYR

2

6TPK

7RYC

P2RY1

2

4XNV, 4XNW

 

P2Y12

3

4PXZ, 4PY0, 4NTJ

 

PAR1

1

3VW7

 

PAR2

3

5NDZ, 5NJ6, 5NDD

 

PTGDR2

3

7M8W, 6D26, 6D27

 

PTGER2

3

 

7CX2, 7CX3, 7CX4

PTGER3

2

6AK3, 6M9T

 

PTGER4

3

5YHL, 5YWY

7D7M

PTAFR

2

5ZKQ, 5ZKP

 

lpar6a

1

5XSZ

 

BLT1

1

5X33

 

S1PR1

11

3V2W, 3V2Y

7TD4, 7TD3, 7EO4, 7EO2, 7EVY, 7WF7, 7EW0, 7EW7, 7EVZ

S1PR2

1

 

7T6B

S1PR3

4

7C4S

7EW2, 7EW3, 7EW4

S1PR5

1

 

7EW1

SSR2

2

 

7T10, 7T11

SUCR1

3

6Z10, 6RNK, 6IBB

 

TBXA2R

2

6IIU, 6IIV

 

V2R

2

 

7DW9, 7BB6

GPR52

4

6LI0, 6LI1, 6LI2

6LI3

GPR88

2

 

7EJX, 7WZ4

GPR139

4

 

7VUH, 7VUJ, 7VUI, 7VUY

GPR183

2

7TUY

7TUZ

MRGX2

14

7VV6, 7VV4, 7VV0

7VDM, 7VDH, 7VUZ, 7VDL, 7VV5, 7VUY, 7VV3, 7S8M, 7S8O, 7S8L, 7S8N

MRGX4

1

 

7S8P

B1

CALCR

12

 

5UZ7, 6NIY, 7TYL, 7TYI, 7TYN, 7TYO, 7TYF, 7TYW, 7TYH, 7TYX, 7TYY, 7TZF

CALRL

6

7KNU, 7KNT

6E3Y, 6UVA, 6UUN, 6UUS

CRFR1

4

4K5Y, 4Z9G

6PB0, 6P9X

CRFR2

1

 

6PB1

GHRHR

2

 

7CZ5, 7V9M

GIPR

6

 

7FIY, 7VAB, 7FIN, 7DTY, 7RBT, 7RA3

GLP1R

34

5NX2, 5VEW, 5VEX, 6KJV, 6KK1, 6KK7, 6LN2

7FIM, 7VBI, 7LLL, 7LLY, 7S1M, 7S3I, 7RTB, 7DUR, 7EVM, 7KI0, 7KI1, 7DUQ, 7E14, 7LCJ, 7LCK, 7LCI, 6XOX, 6X1A, 6X18, 6X19, 7C2E, 6VCB, 6ORV, 6B3J, 7RGP, 7RG9, 7VBH

GLP2R

1

 

7D68

GCGR

10

4L6R, 5EE7, 5XEZ, 5XF1, 5YQZ

6LMK, 6LML, 6WHC, 6WPW, 7V35

SCTR

3

 

6WZG, 6WI9, 7D3S

B2

ADGRG1

1

 

7SF8

ADGRL3

1

 

7SF7

C

GABBR1

1

6W2Y

 

GABBR2

12

7C7S, 7C7Q, 6UO8, 6VJM, 6UOA, 6UO9, 6W2X, 6WIV, 7CUM, 7CA5, 7CA3

7EB2

GRM1

3

4OR2, 7DGE, 7DGD,

 

GRM2

9

7MTR, 7MTQ, 7EPE, 7EPD, 7EPB, 7EPF, 7EPA

7MTS, 7E9G

GRM3

3

7WI6, 7WI8, 7WIH

 

GRM4

1

 

7E9H

GRM5

11

4OO9, 5CGC, 5CGD, 6FFH, 6FFI, 6N4X, 6N4Y, 6N50, 6N51, 6N52, 7FD8, 7P2L, 7FD9

 

GRM7

1

7EPC

 

GP158

5

7EWL, 7SHF, 7SHE, 7EWR, 7EWP

 
 

CASR

16

7SIL, 7SIM, 7SIN, 7E6U, 7E6T, 7M3E, 7M3J, 7M3G, 7M3F, 7DD5, 7DD6, 7DD7, 7DTU,7DTW, 7DTV, 7DTT

 

F

FZD4

1

6BD4

 

FZD5

1

6WW2

 

FZD7

1

 

7EVW

  1. ADRB3 beta-3 adrenergic receptor, AGTR1 type 1 angiotensin II receptor, AGTR2 type 2 angiotensin II receptor, HTR1A 5-hydroxytryptamine receptor 1A, HTR1B 5-hydroxytryptamine receptor 1B, HTR1D 5-hydroxytryptamine receptor 1D, HTR1E 5-hydroxytryptamine receptor 1E, HTR1F 5-hydroxytryptamine receptor 1F, HTR2A 5-hydroxytryptamine receptor 2A, HTR2B 5-hydroxytryptamine receptor 2B, HTR2C 5-hydroxytryptamine receptor 2C, ACM1 muscarinic acetylcholine receptor M1, ACM2 muscarinic acetylcholine receptor M2, ACM3 muscarinic acetylcholine receptor M3, ACM4 muscarinic acetylcholine receptor M4, ACM5 muscarinic acetylcholine receptor M5, APJ apelin receptor, BKRB1 B1 bradykinin receptor, BKRB2 B2 bradykinin receptor, C5AR1 C5a anaphylatoxin chemotactic receptor 1, CCKAR cholecystokinin receptor type A, CCR1 cinnamoyl-CoA reductase 1, CCR2 C-C chemokine receptor type 2, CCR5 C-C chemokine receptor type 5, CCR6 C-C chemokine receptor type 6, CCR7 C-C chemokine receptor type 7, CCR9 C-C chemokine receptor type 9, CNR1 cannabinoid receptor 1, CNR2 cannabinoid receptor 2, CXCR2 C-X-C chemokine receptor type 2, CXC-R4 C-X-C chemokine receptor type 4, DRD1 D(1A) dopamine receptor, DRD2 D(2) dopamine receptor, DRD3 D(3) dopamine receptor, DRD4 D(4) dopamine receptor, EDNRB endothelin receptor type B, FFAR1 free fatty acid receptor 1, FPR1 fMet-Leu-Phe receptor, FPR2 N-formyl peptide receptor 2, GALR1 galanin receptor type 1, GALR2 galanin receptor type 2, CCKBR gastrin/cholecystokinin type B receptor, GHSR growth hormone secretagogue receptor type 1, GNRHR gonadotropin-releasing hormone receptor, GPBAR1 G-protein coupled bile acid receptor 1, HRH1 histamine H1 receptor, LPAR1 lysophosphatidic acid receptor 1, LSHR lutropin-choriogonadotropic hormone receptor, LT4R1 leukotriene B4 receptor 1, MC4R melanocortin receptor 4, MSHR melanocyte-stimulating hormone receptor, MTNR1A melatonin receptor type 1A, MTNR1B melatonin receptor type 1B, NK1R substance-P receptor, NPY1R neuropeptide Y receptor type 1, NPY2R neuropeptide Y receptor type 2, NTSR1 neurotensin receptor type 1, OPRD delta-type opioid receptor, OPRK kappa-type opioid receptor, OPRM mu-type opioid receptor, OPRL1 nociceptin receptor, HCRTR1 orexin/hypocretin receptor type 1, HCRTR2 orexin receptor type 2, OXYR oxytocin receptor, P2RY1 P2Y purinoceptor 1, P2Y12 P2Y purinoceptor 12, PAR1 proteinase-activated receptor 1, PAR2 proteinase-activated receptor 2, PTGDR2 prostaglandin D2 receptor 2, PTGER2 prostaglandin E2 receptor EP2 subtype, PTGER3 prostaglandin E2 receptor EP3 subtype, PTGER4 prostaglandin E2 receptor EP4 subtype, PTAFR platelet-activating factor receptor, lpar6a lysophosphatidic acid receptor 6a, BLT1 leukotriene B4 receptor 1, S1PR1 sphingosine 1-phosphate receptor 1, S1PR2 sphingosine 1-phosphate receptor 2, S1PR3 sphingosine 1-phosphate receptor 3, S1PR5 sphingosine 1-phosphate receptor 5, SSR2 somatostatin receptor type 2, SUCR1 succinate receptor 1, TBXA2R thromboxane A2 receptor, V2R vasopressin V2 receptor, GPR52 G-protein coupled receptor 52, GPR88 probable G-protein coupled receptor 88, GPR139 probable G-protein coupled receptor 139, GPR183 G-protein coupled receptor 183, MRGX2 Mas-related G-protein coupled receptor member X2, MRGX4 Mas-related G-protein coupled receptor member X4, CALCR calcitonin receptor, CALRL calcitonin gene-related peptide type 1 receptor, CRFR1 corticotropin-releasing factor receptor 1, CRFR2 corticotropin-releasing factor receptor 2, GHRHR growth hormone-releasing hormone receptor, GIPR gastric inhibitory polypeptide receptor, GLP1R glucagon-like peptide-1 receptor, GLP2R glucagon-like peptide 2 receptor, GCGR glucagon receptor, SCTR secretin receptor, ADGRG1 adhesion G-protein coupled receptor G1, ADGRL3 adhesion G protein-coupled receptor L3, GABR1 gamma-aminobutyric acid type B receptor subunit 1, GABBR2 gamma-aminobutyric acid type B receptor subunit 2, GRM1 metabotropic glutamate receptor 1, GRM2 metabotropic glutamate receptor 2, GRM3 metabotropic glutamate receptor 3, GRM4 metabotropic glutamate receptor 4, GRM5 metabotropic glutamate receptor 5, GRM7 metabotropic glutamate receptor 7, GP158 probable G-protein coupled receptor 158, CASR extracellular calcium-sensing receptor, FZD4 Frizzled-4, FZD5 Frizzled-5, FZD7 Frizzled-7
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