Fig. 6

kshv-miR-K12-1-5p aggravated cardiotropic viruses-induced cardiac inflammatory infiltration and dysfunction. a Schema of the experimental setup for overexpressing kshv-miR-K12-1-5p via agomiR. i.v. tail vein injection, i.p. intraperitoneal injection. b The CVB3 RNA levels detected by RT-PCR in the heart tissues at different time points. c HE staining of representative heart tissue sections (left) and the inflammation histoscore calculated based on HE staining (right) on day 7 post-infection. Scale bar (up) = 1 mm. Scale bar (down) = 100 µm. d Sirius red staining of representative heart tissue sections (left) and statistical graph (right) on day 14 post-infection. Scale bar = 100 µm. e Schema of the experimental setup for overexpressing kshv-miR-K12-1-5p via rAAV. i.v. tail vein injection, i.p. intraperitoneal injection. f The CVB3 RNA levels detected by RT-PCR in the heart tissues at different time points. g HE staining of representative heart tissue sections (left) and the inflammation histoscore calculated based on HE staining (right) on day 7 post-injection. Scale bar (up) = 1 mm. Scale bar (down) = 100 µm. h Sirius red staining of representative heart tissue sections (left) and statistical graph (right) on day 14 post-injection. Scale bar = 100 µm. n = 6 each. *p < 0.05