Table 5 Main studies on lncRNA in obstructive sleep apnea syndrome (OSAS)/intermittent hypoxia (IH)
From: Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
LncRNA name | Expression in IH | Target | Original source | Quantification approach | Main findings | Reference |
|---|---|---|---|---|---|---|
XR_600374 XR_590196 XR_597099 | Down | Unknown | Heart samples of rats | lncRNA microarray and qRT‒PCR | This study revealed for the first time that OSAS changed the expression profile of lncRNA in the rat heart, which could help us to establish the knowledge base of cardiovascular disease pathogenesis induced by OSAS | Chen et al. (2019)477 |
XR_596701 XR_344474 ENSRNOT00000065561 | Up | |||||
CPS1-IT | Down | HIF-1 | Pulmonary artery tissues of rats | RT‒qPCR | Decreased CPS1-IT could enhance the transcriptional activity of HIF-1, enhance the expression of IL-1β through the NF-κB signaling pathway, and promote pulmonary arterial hypertension in OSAS | Zhang et al. (2019)478 |
MALAT1 | Up | miR-224-5p | Mouse brain tissues and the microglial BV2 mouse cell line | qRT‒PCR | IH increased the expression of MALAT1, further inhibited the expression of miR-224-5p, and finally regulated the NLRP3/IL-1β pathway and promoted hippocampal inflammation | Du et al. (2020)481 |
MEG3 | Up | miR135a | Aortic endothelial tissues of mice | RT‒qPCR | IH induced increased expression of MEG3, and targeted miR-135a upregulated HIF-1α to promote aortic endothelial injury and apoptosis in IH mice | Ding et al. (2020)482 |
ROR | Up | miR-145 | HK-2 cells | qRT‒PCR | ROR alleviated CoCl2-induced hypoxia injury through the regulation of miR-145 | Ge et al. (2019)700 |
ENST00000592016 | Up | Unknown | Plasma exosomes of OSAS patients | qRT‒PCR | The level of ENST00000592016 is correlated with the severity of OSAS and can be used as a diagnostic marker for OSAS | Chen et al. (2022)701 |
MRPL20-AS1 | Down | Unknown | Male human coronary artery cells | qRT‒PCR | MRPL20-AS1 might serve as a useful tool to identify patients with severe OSAS | Zietzer et al. (2022)702 |
NONMMUT032513 | Up | ZEB1 and smad5; Cmbl and ADH5 (unverified) | Mouse heart tissues | Microarray and qRT‒PCR | LncRNAs might be responsible for myocardial infarction aggravation under OSAS | Hu et al. (2021)703 |
NONMMUT074571 | ZEB1 and Smtn; Cmbl and Pfdn6 (unverified) | |||||
XIST | Up | GRα | The adenoids of patients with OSAS and NP69 cells | qRT‒PCR | XIST reduces the expression of GRα through the NF-κB-dependent signaling pathway, thereby promoting the occurrence and development of OSAS | Zhou et al. (2021)704 |
XR_595552 | Up | PI3K/AKT pathway | H9c2 cells | qRT‒PCR | XR_595552 may play a protective role in alleviating IH-induced cardiomyocyte injury by regulating the PI3K/AKT pathway | Chen et al. (2023)705 |
