Fig. 5

a The 52 significant altered metabolites among AR, PI, and EF. The comparison between two groups was tested by the Student’s t test. b The correlation of the selected fecal microbiome with serum metabolites. The significantly correlated (calculated by Spearman correlation, p < 0.01) species and metabolite are showed in the cycle. Species and metabolites with enrichment in either AR, PI, or EF samples are indicated by the colored bar of the inside track. The phylum of the microbiome and class metabolites are indicated by the colored bar of outside the track. The green and yellow lines represent positive and negative correlation, respectively