Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Immunotherapy in hematologic malignancies: achievements, challenges and future prospects

Fig. 3

The evolution of CAR design and the process of CAR-T therapy in clinic. a The design of the CAR has undergone several updates throughout the evolution of CAR-T therapy. To date, there have been five generations of CAR structures. b CAR-T cell therapy is a multi-step process that involves selecting eligible patients, collecting cells, manufacturing CAR-T cells, lymphodepletion and infusion of CAR-T cells and subsequent longitudinal follow-up

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