Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: TET (Ten-eleven translocation) family proteins: structure, biological functions and applications

Fig. 1The alternative text for this image may have been generated using AI.

Function and structure of TET proteins. a The dynamic cycle of DNA methylation and demethylation. DNA methyltransferases (DNMTs) catalyzed the formation of 5-methylcytosine (5mC), which can be removed by TET-mediated oxidation, coupled with thymine-DNA glycosylase (TDG)-involved excision and base excision repair (BER). b Domain structure of TET proteins. All TET proteins possessed one core catalytic domain in C-terminal. A CXXC domain, located in the N-terminal of TET1 and TET3, but not in TET2, conferred DNA binding ability directly

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