Table 1 Different types of TET1 binding proteins and their functions
From: TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
Type | Name[reference] | Effects | TET1 catalytic dependent; substrates |
|---|---|---|---|
Transcription factors | PPARγ335 | Recruit TET1 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
| Â | Zfp281336 | Â | Â |
| Â | FOXA1201 | Â | Â |
| Â | EGR1337 | Â | Â |
| Â | NANOG338 | Â | Â |
| Â | STAT1100 | Â | Â |
| Â | TEAD339 | Â | Â |
| Â | FOXA2340 | Â | Â |
| Â | GFI1341 | Recruit polycomb cofactors; Repress target transcription | No |
Post-translational modification Enzymes | KAT8342 | Recruit KAT8; Enhance gene transcription | No |
| Â | HDAC1183 | Recruit HDAC1; Repress gene transcription | No |
| Â | SIRT1343 | Enhance SIRT1 deacetylase activity | No |
RNA-binding proteins | Lin28A344 | Recruit TET1 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
| Â | NONO345 | Â | Â |
| Â | FXR1101 | Â | Â |
LncRNA | AC092723.1346 | Recruit TET1 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
Others | RBAP46347 | Recruit TET1 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
| Â | SIN3A348 | Â | Â |
| Â | GADD45A349 | Â | Â |
| Â | GADD45B350 | Â | Â |
| Â | SUZ12351 | Recruit TET1 to specific DNA sites; Enhance 5hmC formation | Yes;5mC |
| Â | QSER1352 | Recruit TET1 to specific DNA sites; Repress DNMT3-mediated de novo methylation | No |
