Table 3 Different types of TET3 binding proteins and their functions
From: TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
Type | Name[reference] | Effects | TET3 catalytic dependent; substrates |
|---|---|---|---|
Transcription factors | FOXA2138 | Recruit TET3 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
|  | TRα1369 | Stabilize TRα1 protein | No |
|  | HNF4α370 | Recruit TET3 to specific DNA sites; Enhance 5hmC formation | Yes;5mC |
Post-translational modification Enzymes | HDAC1371 | Recruit HDAC1; Repress gene transcription | No |
| Â | OGT372 | Catalyze TET3 O-GlcNAcylation; Promote cytoplasmic localization | N/A |
Others | Suppress TET3 activity | N/A | |
| Â | glutamate dehydrogenase235 | Enhance TET3 activity | N/A |
| Â | REST63 | Recruit TET3 to specific DNA sites; Enhance target gene transcription | Yes;5mC |
| Â | SIN3A371 | Recruit SIN3A; Repress gene transcription | No |
| Â | GSE374 | Recruit TET3 to specific DNA sites; Enhance 5hmC formation | Yes;5mC |
