Table 4 Representative mouse models with TETs loss of function
From: TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
TETs loss of function | Major phenotypes | References |
|---|---|---|
TET1 knockout | B cell malignancies | |
TET2 knockout | CMML-like | |
TET3 knockout | Neonatal lethality | |
TET1/2 double knockout | B-lymphoid malignancies | |
TET1/3 double knockout | Embryonic lethality | |
TET2/3 double knockout | Myeloid leukemia | |
TET1/2/3 triple knockout | Embryonic lethality |
