Table 1 Effects of NMN on BP, metabolic parameters and vascular function

From: NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

 

LM (n = 10)

NMN (n = 9)

Pdifference

Baseline

6 weeks

P

Baseline

6 weeks

P

Demographics

Age (years)

46.70 ± 11.19

46.70 ± 11.19

–

46.00 ± 12.86

46.00 ± 12.86

–

0.40

Male sex [n (%)]

5 (50.00%)

5 (50.00%)

–

4 (44.44%)

4 (44.44%)

–

0.81

Body weight (kg)

62.90 ± 10.08

62.80 ± 9.84

0.59

62.72 ± 22.91

62.67 ± 7.78

0.84

0.89

BMI (kg/m2)

22.92 ± 1.86

22.89 ± 1.77

0.61

22.91 ± 3.41

22.88 ± 3.46

0.80

0.96

Smoking [n (%)]

1 (10.00%)

1 (10.00%)

–

1 (11.11%)

1 (11.11%)

–

0.94

BP

SBP (mmHg)

136.40 ± 5.78

133.90 ± 5.90

0.07

136.22 ± 7.61

129.33 ± 5.50

<0.001

0.014

DBP (mmHg)

82.90 ± 5.51

81.91 ± 5.11

0.51

82.89 ± 6.57

79.33 ± 4.72

0.08

0.28

Metabolic indices

Fasting serum glucose (mmol/L)

5.02 ± 0.57

5.09 ± 0.81

0.83

4.48 ± 0.35

4.34 ± 0.28

0.46

0.59

Total cholesterol (mmol/L)

4.57 ± 0.76

4.63 ± 0.76

0.75

5.39 ± 1.28

5.54 ± 1.09

0.66

0.80

Triglyceride (mmol/L)

1.67 ± 1.37

1.55 ± 1.40

0.65

1.22 ± 0.68

1.08 ± 0.47

0.41

0.93

HDL cholesterol (mmol/L)

1.36 ± 0.36

1.40 ± 0.35

0.37

1.34 ± 0.24

1.34 ± 0.27

0.94

0.63

LDL cholesterol (mmol/L)

2.69 ± 0.55

2.78 ± 0.51

0.48

3.49 ± 0.94

3.62 ± 0.82

0.62

0.89

ALT (U/L)

23.50 ± 14.45

22.90 ± 8.75

0.86

19.89 ± 12.73

23.33 ± 14.65

0.42

0.45

AST (U/L)

23.80 ± 8.94

26.20 ± 11.16

0.60

21.44 ± 6.88

24.78 ± 7.87

0.18

0.86

Creatinine (μmol/L)

71.20 ± 25.62

71.40 ± 22.81

0.93

73.89 ± 16.52

74.67 ± 16.94

0.75

0.86

Uric acid (μmol/L)

358.60 ± 98.45

328.80 ± 116.39

0.13

339.44 ± 79.12

336.33 ± 55.09

0.85

0.28

Vascular function

FMD (%)

5.60 ± 1.71

5.67 ± 1.67

0.72

5.46 ± 2.23

6.39 ± 2.45

0.031

0.042

baPWV (cm/s)

1443.50 ± 130.55

1422.70 ± 121.38

0.19

1434.22 ± 182.23

1317.56 ± 134.41

0.006

0.01

Inflammatory indices

Hs-CRP (mg/L)

0.92 ± 0.74

0.84 ± 0.71

0.09

1.16 ± 1.18

0.88 ± 0.73

0.54

0.64

Serum IL-1β (ng/L)

0.34 ± 0.24

0.34 ± 0.26

0.92

0.29 ± 0.19

0.22 ± 0.14

0.049

0.28

Serum IL-6 (ng/L)

14.03 ± 13.24

13.04 ± 11.24

0.53

13.26 ± 17.82

11.09 ± 15.87

0.14

0.57

Serum IL-18 (ng/L)

12.43 ± 11.39

12.10 ± 9.41

0.75

12.50 ± 12.40

11.75 ± 8.50

0.77

0.87

  1. Two-sided paired t test or Wilcoxon signed rank test was used for the comparison within groups. Independent sample t test was performed in the comparisons of difference of two group. Continuous variables are expressed as mean ± SD for parametric variables and as median (interquartile range) for non-parametric variables. Pdifference in age, male sex, smoking indicates the P value of difference of baseline while the other Pdifference indicates the P value of differences before and after intervention between LM and NMN group
  2. LM life modification, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, HDL high-density lipoprotein, LDL low-density lipoprotein, IL interleukin, TNF tumor necrosis factor, FMD flow mediated dilation, baPWV brachial ankle pulse wave velocity
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