Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: The role of cell death in SARS-CoV-2 infection

Fig. 2

The necroptosis pathway during SARS-CoV-2 infection. SARS-CoV-2 ORF7b promotes the expression of death ligands (such as TNF-α, FasL, and IFN-γ). SARS-CoV-2 NSP12 can interact directly with and stimulate RIPK1 activation. SARS-CoV-2 ORF3a and E form a Ca2+ permeable cation channel to induce necroptosis. In addition, SARS-CoV-2 stimulates TLRs pathway and viral ZBP1 axis, directly activating RIPK3 to trigger necroptosis

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