Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

Fig. 4

Cluster analysis and correlation analysis of the significantly different expression genes from tumor tissues within ECM receptor interaction and complement & coagulation cascades signalings. a The gene-gene interaction network of the treatment response-related genes involved in ECM receptor interaction and complement & coagulation cascades signalings in tumors. The gene connection clusters are colored red (Cluster 1), green (Cluster 2), and blue (Cluster 3). The solid and the dotted lines indicate connection within the same and different clusters respectively. b A heatmap showing the correlation of the 25 treatment response-related genes with the oncological features including apoptosis, EMT, and proliferation in tumors (Spearman Correlation test, p < 0.05)

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