Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

Fig. 5

Key events involved in mTOR-mediated autophagy. The mTORC1 suppressed the ULK1 complex activity via phosphorylation of ULK1/ATG13. The mTORC1 can help in the translocation of TFEB in the nuclear compartment to regulate the process of autophagy. The mTORC1 has an important role in the induction of autophagy, nucleation, phagosome elongation, autolysosome formation, and finally degradation through lysosomes. Created with BioRender.com

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