Fig. 8
From: Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
eEF2K-mediated control of CD4+ T cells restrain inflammatory diseases. Mice deficient in eEF2K exhibited an elevated metabolic profile and enhanced production of pro-inflammatory cytokines. eEF2K was found to modulate mitochondrial bioenergetics and redox balance by influencing STAT3, thereby exerting an impact on CD4+ T cell function. The depletion of eEF2K led to the development of Th17-related autoimmune diseases, such as colitis, through the STAT3 pathway. This figure was created with BioRender.com
