Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

Fig. 2

Transcriptional co-activators: Interplay with co-repressors and involvement in developmental and metabolic disorders. a In healthy individuals, cellular homeostasis is perpetuated by a dynamic equilibrium between the transcriptional co-activators (Co-A) and co-repressors (Co-R), that fine tunes the balance between cell proliferation and cell death signals. However, during disease conditions, like malignant transformation, the balance is skewed towards those co-regulators (both co-A and co-R) that mediate cell proliferation signals. Context-specific gain-of-function or loss-of-function mutations of transcriptional co-regulators mediate upregulation of oncogenic transcriptional signaling, thereby facilitating cancer promotion and progression. b Involvement of transcriptional co-activators in three common developmental disorders (ASD autism spectrum disorder, ADHD attention deficit/hyperactivity disorder, ID intellectual disability) and two of the most prevalent metabolic disorders, diabetes and obesity. This figure was created using BioRender (https://biorender.com/)

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