Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Fig. 1

Timeline of key milestones in the development of hypoxia signaling in cardiovascular diseases. Abbreviations: APCs antigen-presenting cells, E8.5 embryonic day 8.5, EPO erythropoietin, FIH factor-inhibiting HIF, HIF hypoxia inducible factor, HO-1 heme oxygenase-1, I/R ischemia/reperfusion, iNOS inducible nitric oxide synthase, IPC ischemic preconditioning, LDHA lactate dehydrogenase, Oct-4 octamer-binding transcription factor 4, PGK phosphoglycerate kinase, PHD prolyl hydroxylases, Rbx1 ring-box protein 1, SIRT Sirtuin, VEGF vascular endothelial growth factor, VHL von Hippel-Lindau, YAP1 Yes-associated protein 1

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