Fig. 3
From: Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Epigenetic control of hypoxia signaling in cardiovascular diseases. a Post-translational modifications of histones and DNA methylation modifications. b The crucial role of Hsp90’s chaperone function in the regulation of HIF-1α stability. c The functional impact of lactylation modification in myocardial infarction. d The functional impact of lactylation modification in PAH. e The functional impact of DNA methylation modifications in PAH. f The influence of non-coding RNA on endothelial function under conditions of hypoxia or local hemodynamic disturbance. g The functional impact of long non-coding RNA in PAH. (Created with BioRender.com). Abbreviations: 3′-UTR 3′ Untranslated Region, AAV1 adeno-associated virus serotype 1, AR aortic regurgitation, Bmp5 bone morphogenetic protein 5, BMPR2 bone morphogenetic protein receptor type 2, CaCNα1C L-type calcium channel-α 1C, CTCF CCCTC-binding factor, DNMT DNA methyltransferase, ECs endothelial cells, EndoMT endothelial-to-mesenchymal transition, eNOS endothelial nitric oxide synthase, EZH2 enhancer of zeste homolog 2, FHL1 four and a half LIM domains 1, HAT histone acetyltransferase, HCM hypertrophic cardiomyopathy, HDAC histone deacetylase, hnRNP E1 heterogeneous nuclear ribonucleoprotein E1, IGF1R insulin-like growth factor 1 receptor, KDM lysine demethylase, Kit stem cell factor receptor, KMT lysine methyltransferase, lncRNA-MEG3 long non-coding RNA Maternally Expressed Gene 3, MCT monocarboxylate transporter, MI myocardial infarction, miR-185 microRNA-185, miR-328-3p microRNA-328-3p, miR-765 microRNA-765, mPAP mean pulmonary arterial pressure, PAH pulmonary arterial hypertension, PASMC pulmonary artery smooth muscle cell, PIM1 proviral integration site for moloney murine leukemia virus 1, RNAP II RNA polymerase II, ROS reactive oxygen species, RVSP right ventricular systolic pressure, SIN3α switch-insensitive 3a, SLC2A3 solute carrier family 2 member 3, Smad2 mothers against decapentaplegic homolog 2, Snail1 snail family transcriptional repressor 1, SuHx sugen/hypoxia, TET ten-eleven translocation, TGF-β transforming growth factor-β, Trpc5 transient receptor potential cation channel subfamily c member 5
