Fig. 4
From: Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
HIFs associated with natural rhythms in cardiovascular diseases. a HIFs related to circadian rhythms. b HIFs related to hibernation. (Created with BioRender.com). Abbreviations: Adora2b adenosine A2b receptor, AKT protein kinase B, ATP adenosine triphosphate, BMAL1 brain and muscle Arnt-like protein 1, cAMP cyclic adenosine monophosphate, CLOCK circadian locomotor output cycles kaput, CRY cryptochrome, E-BOX enhancer box, ipRGCs intrinsically photosensitive retinal ganglion cells, LKB1 liver kinase B1, Meis1 myeloid ecotropic viral integration site 1 homolog, mTOR mechanistic target of rapamycin, NRF2 nuclear factor erythroid 2-related factor 2, p53 tumor protein p53, PAI1 plasminogen activator inhibitor-1, PER period, PI3K phosphatidylinositol 3-kinase, PTEN phosphatase and tensin homolog, PTL protein triacylglycerol lipase, REV-ERBα reverse erythroblastosis virus α, RORE retinoic acid receptor-related orphan receptor response elemen, RORα retinoic acid receptor-related orphan receptor alpha, SCN suprachiasmatic nucleus, TSC1/2 tuberous sclerosis complex 1/2
