Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

Fig. 2

Gene Differential Expression Analysis in BALF of COVID-19 Patients. a Volcano plot comparing gene expression between the survival and non-survival groups of COVID-19 patients. 489 genes were up-regulated and 187 genes were down-regulated in the survival group (abs(FC) > 1.5, p-value < 0.05), including red-highlighted genes that were functionally characterized or implicated in subsequent analyses. b Gene Ontology (GO) enrichment analysis (Biological Process) of the differentially expressed genes identified in (a), where the representative genes involved in each GO term are indicated in parentheses. c Volcano plot displaying genes with differential expression between COVID-19 patients and HAP/CAP patients, which are also differentially expressed in the survival group of COVID-19 patients. These genes are specific to COVID-19 survival patients and include 268 up-regulated and 97 down-regulated genes. d KEGG enrichment analysis of the differentially expressed genes identified in (c). HAP/CAP patients (n = 27), COVID-19 patients (n = 63), non-survivors of the invasive ventilated COVID-19 patients (n = 45), survivors of the invasive ventilated COVID-19 patients (n = 18)

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