Table 1 Clinical Characteristics of the Study Population
Survival (n = 19) Median (IQR) | Death (n = 45) Median (IQR) | P value | |
|---|---|---|---|
Age, yr | 80.00 (16.00) | 80.00 (13.00) | 0.49 |
Sex | 0.22 | ||
Male, n (%) | 16.00 (84.21) | 32.00 (75.00) | |
Female, n (%) | 3.00 (15.79) | 13.00 (25.00) | |
Co-morbiditya, n (%) | 16.00 (84.21) | 42.00 (93.33) | 0.25 |
SOFA score | 8.00 (4.00) | 11.00 (5.00) | <0.01 |
APACHE II score | 19.00 (4.00) | 26.00 (3.00) | <0.01 |
PaO2/FiO2 | 188.00 (199.00) | 132.86 (144.35) | 0.02 |
D-dimer (μg/L) | 2270.00 (5626.00) | 2012.00 (3492.00) | 0.45 |
Lactic acid(mmol/L) | 1.50 (1.30) | 2.00 (1.30) | 0.15 |
BNP(pg/ml) | 209.00 (615.00) | 278.50 (717.00) | 0.33 |
TnI(pg/mL) | 21.89 (128.65) | 13.50 (49.20) | 0.70 |
CK-MB(ng/mL) | 3.00 (5.77) | 3.58 (12.70) | 0.19 |
ALT(U/L) | 21.00 (54.40) | 22.80 (25.20) | 0.92 |
AST(U/L) | 29.90 (42.90) | 36.05 (24.70) | 0.71 |
Total bilirubin (μmol/L) | 12.90 (9.00) | 13.60 (9.55) | 0.49 |
Albumin (g/L) | 30.60 (7.80) | 30.10 (7.35) | 0.06 |
Creatinine (μmol/L) | 88.00 (67.55) | 81.50 (89.44) | 0.38 |
BUN(mmol/L) | 11.33 (9.16) | 11.90 (11.08) | 0.73 |
UA(μmol/L) | 262.30 (184.80) | 292.80 (171.80) | 0.55 |
GLU(mmol/L) | 8.12 (5.24) | 9.93 (8.05) | 0.51 |
Neutrophil(109/L) | 7.75 (6.36) | 10.12 (8.40) | 0.21 |
Neutrophil percentage(%) | 91.00 (6.30) | 92.40 (10.00) | 0.17 |
Lymphocyte (109/L) | 0.51 (0.40) | 0.45 (0.37) | 0.19 |
Lymphocyte percentage (%) | 5.00 (4.20) | 4.20 (5.10) | 0.16 |
Platelet (109/L) | 124.40 (85.00) | 171.00 (138.50) | 0.10 |
Erythrocyte(1012/L) | 3.71 (1.58) | 3.74 (1.07) | 0.99 |
Leukocyte(109/L) | 8.57 (6.37) | 11.60 (8.73) | 0.44 |
Monocyte(109/L) | 0.39 (0.67) | 0.39 (0.36) | 0.93 |
BALF cytokine | Survival (n = 19) | Death (n = 45) | |
IL-5(pg/mL) | 3.15 (6.30) | 4.95 (3.53) | 0.18 |
IFN-α(pg/mL) | 4.56 (3.27) | 5.99 (4.86) | 0.05 |
IL-2(pg/mL) | 2.32 (1.96) | 2.67 (2.02) | 0.07 |
IL-6(pg/mL) | 506.78 (1448.00) | 610.73 (1386.36) | 0.30 |
IL-1β(pg/mL) | 277.98 (1255.93) | 919.89 (3290.46) | 0.05 |
IFN-γ(pg/mL) | 12.85 (8.13) | 19.61 (28.10) | 0.05 |
IL-8(pg/mL) | 7864.79 (9553.95) | 8930.17 (8409.79) | 0.25 |
IL-17(pg/mL) | 3.53 (2.74) | 4.39 (2.89) | 0.04 |
IL-12P70(pg/mL) | 2.73 (1.25) | 2.90 (1.64) | 0.15 |
TNF-α(pg/mL) | 9.24 (23.08) | 22.14 (46.99) | <0.01 |
IL-4(pg/mL) | 2.98 (1.92) | 3.00 (2.04) | 0.25 |
IL-10(pg/mL) | 3.58 (2.60) | 3.53 (3.67) | 0.05 |
Plasma cytokine | Survival (n = 18) | Death (n = 42) | |
IL-5(pg/mL) | 2.86 (2.23) | 1.81 (2.56) | 0.02 |
IFN-α(pg/mL) | 1.65 (2.50) | 1.25 (1.89) | 0.17 |
IL-2(pg/mL) | 1.41 (1.60) | 1.25 (0.72) | 0.22 |
IL-6(pg/mL) | 21.16 (294.59) | 254.58 (761.84) | 0.03 |
IL-1β(pg/mL) | 1.57 (11.70) | 0.00 (4.52) | 0.20 |
IFN-γ(pg/mL) | 4.44 (7.97) | 3.79 (7.97) | 0.39 |
IL-8(pg/mL) | 14.51 (15.87) | 21.25 (38.41) | 0.06 |
IL-17(pg/mL) | 2.95 (1.73) | 3.11 (2.33) | 0.25 |
IL-12P70(pg/mL) | 1.75 (0.35) | 1.76 (0.35) | 0.47 |
TNF-α(pg/mL) | 0.41 (4.71) | 0.77 (2.57) | 0.46 |
IL-4(pg/mL) | 1.46 (0.31) | 1.48 (0.42) | 0.49 |
IL-10(pg/mL) | 2.17 (2.42) | 4.66 (7.58) | <0.01 |
