Fig. 4

The lymphatic vessels in meninge and eyes. a The meningeal lymphatic vessels are mainly located at the dural region abut to the cranium, and developing along the cerebral vessels and nerves. Meningeal lymphatic vessels enter the nasal submucosal interstitium traveling through cribriform plate and form nasal lymphatic vessels extracranially, partly participating in the extracranial CSF drainage; b The meningeal lymphatic vessels exchange CSF with glymphatic system at subarachnoid space and eventually drain it into dcLNs; c SC abuts juxtacanalicular region of the TM, consisting of inner and outer wall constituted by heterogeneous endothelial cells. The inner wall could sense flow and transport aqueous humor into the SC and further drain to downstream episcleral veins; d The ocular surface lymphatic vessels originate from the nasal canthus and encircle laterally along the corneal limbus and the bulbar conjunctiva. CSF cerebrospinal fluid, dcLNs deep cervical lymph nodes, SC Schlemm’s canal, TM trabecular meshwork. Created with Adobe Illustrator