Table 1 The summary of currently WHO-approved/PQ evaluating COVID-19 vaccines

mRNA

Nucleoside modified mRNA

Pfizer-BioNTech

BNT162b2/ Comirnaty Tozinameran (INN)

Wild-type

30 µg RNA (2×)

¹⁰

Comirnaty COVID-19 (Bivalent)

BA.4, BA.5

30 µg RNA (2×)

¹¹

Comirnaty Bivalent Original/Omicron BA.1

Wild-type, BA.1

N/A

¹²

mRNA-based vaccine encapsulated in lipid nanoparticle (LNP)

Moderna Biotech

mRNA-1273

Wild-type

100 µg RNA (2×)

¹³

mRNA-1273.214

Wild-type, BA.1

100 µg RNA (2×)

^14,15

mRNA-1273.222

Wild-type, BA.4/5

100 µg RNA (2×)

¹⁶

CureVac

Zorecimeran (INN)

Wild-type

N/A

¹³

RNA vaccine

Arcturus Therapeutics

ARCT-154

Wild-type

5 µg RNA (2×)

¹⁷

Gennova Biopharmaceuticals Limited

GEMCOVAC-19

Wild-type

N/A

¹²

Adenovector

Recombinant ChAdOx1 adenoviral vector encoding the Spike protein

AstraZeneca, AB

ChAdOx1 (AZD1222)

Wild-type

5 × 10¹⁰ adenovirus vector particles (2×)

¹⁸

R-PHARM

Vaccine R-COVI

N/A

¹³

Recombinant, replication-incompetent adenovirus type 26 (Ad26) vectored vaccine encoding the Spike protein

Janssen–Cilag International NV

Ad26.COV2.S

Wild-type

5 × 10¹⁰ adenovirus vector particles (1×)

¹⁹

Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)

CanSino Biological Inc.

Ad5-nCoV/Convidecia

Wild-type

5 × 10¹⁰ adenovirus vector particles (2×)

²⁰

CanSino Biological Inc.

Convidecia Air^TM

Wild-type

1 × 10¹⁰ adenovirus vector particles (2×)

¹³

Human Adenovirus rAd26 and rAd5 Vector-based Covid-19 vaccine

Gamaleya

Sputnik V

Wild-type

10 × 10¹⁰ adenovirus vector particles (2×)

²¹

Inactivated

Inactivated, produced in Vero cells

Beijing Institute of Biological Products Co., Ltd. (BIBP)

SARS-CoV-2 Vaccine (Vero Cell), Inactivated (lnCoV)

Wild-type

N/A

¹³

Sinovac Life Sciences Co., Ltd.

Coronavac^TM

Wild-type

3 µg proposed (2×)

¹³

Bharat Biotech, India

iNCOVACC

Wild-type

N/A

¹²

Chumakov Center

KoviVac

Wild-type

N/A

¹²

Health Institutes of Turkey

Turkovac

Wild-type

N/A

¹²

Organization of Defensive Innovation and Research

FAKHRAVAC (MIVAC)

Wild-type

N/A

¹²

Shenzhen Kangtai Biological Products Co

KCONVAC

Wild-type

N/A

¹²

Shifa Pharmed Industrial Co

COVIran Barekat

Wild-type

N/A

¹²

Sinopharm (Beijing)

Covilo

Wild-type

N/A

^12,22

Research Institute for Biological Safety Problems (RIBSP)

QazVac

Wild-type

N/A

¹³

Valneva

VLA2001

Wild-type

N/A

¹³

Sinopharm / WIBP

Inactivated SARS-CoV-2 Vaccine (Vero Cell)

Wild-type

N/A

¹³

Shifa Pharmed - Barkat

CovIran® vaccine

Wild-type

N/A

¹³

Whole-Virion Inactivated Vero Cell

Bharat Biotech, India

COVAXIN

Wild-type

6 µg proposed (2×)

¹³

Subunit

Recombinant nanoparticle prefusion spike protein formulated with Matrix-M™ adjuvant

Novavax, Inc.

NVX-CoV2373/Covovax

Wild-type

5 µg S (+50 µg adjuvant) (2×)

¹³

SK Bioscience

Nuvaxovid

Wild-type

5 µg S (+50 µg adjuvant) (2×)

¹³

Recombinant protein subunit

SK Bioscience

GBP510

Wild-type

N/A

¹³

Sanofi

CoV2 preS dTM-AS03 vaccine

Wild-type

N/A

²³

Zhifei Longcom, China

Recombinant Novel Coronavirus Vaccine (CHO Cell)

Wild-type

25 µg NCP-RBD (+adjuvant) (3×)

¹³

Sanofi/GSK

VidPrevtyn Beta

Beta

N/A

¹³

Nanogen

Nanocovax

Wild-type

N/A

²⁴

Cinnagen

SpikoGen

Wild-type

N/A

¹³

Sinocelltech, Ltd

SCTV01C

Alpha, Beta

N/A

¹³

Medigen

MVC-COV1901

Wild-type

N/A

¹³

Center for Genetic Engineering and Biotechnology (CIGB)

Abdala

Wild-type

50 mcg RBD + 0.30 mg aluminum hydroxide

²⁵

Razi Vaccine & Serum Research Institute

Razi Cov Pars Vaccine

Wild-type

N/A

¹³

WestVac Biopharma

Recombinant COVID-19 Vaccine

Wild-type

N/A

¹³

Stelis Biopharma Limited

AKS-452 Vaccine (AmbiVax-C^TM)

Wild-type

two 45 μg doses or a single 90 μg dose

²⁶

PT Biofarma

SARS CoV-2 RBD

Wild-type

N/A

¹³

Bagheiat-allah University of Medical Sciences

Noora vaccine

Wild-type

80 μg of recombinant RBD protein (+adjuvant) (2×)

^12,27

Instituto Finlay de Vacunas Cuba

Soberana 02

Wild-type

50 µg RBD

¹²

Instituto Finlay de Vacunas Cuba

Soberana Plus/ FINLAY-FR-1A

Wild-type

50 µg RBD

¹²

National Vaccine and Serum Institute

Recombinant SARS-CoV-2 Vaccine (CHO Cell)

Wild-type

N/A

¹²

Livzon Mabpharm Inc

V-01

Wild-type

10 μg of fusion protein (+adjuvant) (2×)

^12,28

SK Bioscience

SK Bio-SKYCovione

Wild-type

N/A

¹²

Biological E

Corbevax

Wild-type

N/A

¹³

HIPRA

BIMERVAX

Alpha, Beta

N/A

Liaoning Yisheng Biopharma Co.

PIKA recombinant protein

N/A

N/A

¹³

Plant-based virus-like particle (VLP), recombinant protein

Medicago

COVIFENZ®

Wild-type

N/A

¹³

Modified recombinant spike protein

Shionogi & Co., Ltd

S-268019

Wild-type

N/A

¹³

Recombinant SARS-CoV-2 Spike-Trimer fusion protein

Clover Biopharmaceuticals

SCB-2019

Wild-type

30 μg S (+adjuvant) (2×)

²⁹

Protein-peptide vaccine

Vaxxinity

UB-612

Wild-type

N/A

¹³