Fig. 27 | Signal Transduction and Targeted Therapy

Fig. 27

From: G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery

Fig. 27The alternative text for this image may have been generated using AI.

Allosteric binding sites in the transmembrane domain within 7TMD of GPCRs and corresponding small-molecule allosteric modulators. Stick models of small-molecule ligands are mapped to representative member CRF1R, PDB: 4K5Y. The number of unique modulators is indicated in boldface type, and the number of GPCRs containing the pocket is provided in parentheses

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