Fig. 30 | Signal Transduction and Targeted Therapy

Fig. 30

From: G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery

Fig. 30The alternative text for this image may have been generated using AI.

a Schematic representation of the allosteric agonist PCO371 bound to PTH1R (PDB: 8GW8). b Detailed binding modes of PTH1R binding to PCO371. Hydrogen bonds are presented as orange dashes. c Superposition of the PTH1R bound to PCO371 (displayed in pink) and PTH (displayed in blue) reveals conformational changes upon PCO371 binding

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