Table 1 Baseline characteristics of study participants by MTHFR C677T genotype

From: Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention

MTHFR C677T genotype

 

MTHFR 677 CC/CT

MTHFR 677 TT

 

(N = 8173)

(N = 3012)

 

Enalapril group

Enalapril–folic acid group

Enalapril group

Enalapril–folic acid group

N

4076

4097

1507

1505

Sex

Male, n (%)

1583 (38.84%)

1546 (37.73%)

576 (38.22%)

593 (39.40%)

Age, years

59.37 ± 7.65

59.52 ± 7.51

59.64 ± 7.48

59.42 ± 7.51

Body mass index, kg/m2

25.58 ± 3.59

25.62 ± 3.61

25.61 ± 3.57

25.66 ± 3.58

Baseline SBP, mm Hg

168.14 ± 20.83

167.81 ± 20.61

168.35 ± 21.30

167.99 ± 21.23

Baseline DBP, mm Hg

94.98 ± 12.06

94.93 ± 11.80

95.16 ± 12.09

95.39 ± 11.28

Smoking status

Never

2837 (69.60%)

2910 (71.03%)

1087 (72.13%)

1058 (70.30%)

Former

339 (8.32%)

292 (7.13%)

104 (6.90%)

124 (8.24%)

Current

900 (22.08%)

895 (21.85%)

316 (20.97%)

323 (21.46%)

Alcohol consumption

Never

2882 (70.71%)

2955 (72.13%)

1093 (72.53%)

1071 (71.16%)

Former

278 (6.82%)

259 (6.32%)

98 (6.50%)

100 (6.64%)

Current

916 (22.47%)

883 (21.55%)

316 (20.97%)

334 (22.19%)

Laboratory tests

Total cholesterol, mmol/l

5.64 ± 1.17

5.68 ± 1.19

5.66 ± 1.20

5.63 ± 1.16

Triglycerides, mmol/l

1.70 ± 0.97

1.73 ± 1.81

1.73 ± 0.97

1.68 ± 1.02

HDL-C, mmol/l

1.32 ± 0.36

1.33 ± 0.37

1.31 ± 0.36

1.32 ± 0.36

Fasting glucose#, mmol/l

6.06 ± 1.76

6.04 ± 1.78

6.17 ± 1.95

6.10 ± 1.86

Creatinine, umol/l

64.63 ± 16.37

64.99 ± 18.58

64.14 ± 15.24

66.20 ± 27.51**

tHcy#, umol/l

12.73 ± 5.20

12.87 ± 5.25

19.69 ± 13.54

19.95 ± 13.57

Folic acid#, ng/ml

8.16 ± 3.34

8.09 ± 3.15

7.04 ± 3.13

6.95 ± 3.08

PCT, %

0.19 ± 0.05

0.19 ± 0.06

0.19 ± 0.06

0.19 ± 0.05

MPV, fL

7.63 ± 1.44

7.67 ± 1.76

7.65 ± 1.64

7.63 ± 0.66

PDW, %

15.52 ± 0.39

15.54 ± 0.32**

15.57 ± 1.09

15.54 ± 0.32

PLT, *109/l

255.77 ± 84.92

253.06 ± 69.74

256.19 ± 70.74

258.58 ± 71.65

  1. Values are number (%) or mean ± SD
  2. DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, MPV mean platelet volume, PCT plateletcrit, PDW platelet distribution width, PLT platelet count, SBP systolic blood pressure, tHcy total homocysteine, MTHFR methylenetetrahydrofolate reductase
  3. **Indicates p value < 0.05 among the treatment groups (enalapril vs. enalapril-folic acid); #indicates p value <0.05 among the MTHFR C677T genotypes (CC/CT vs. TT)
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