Fig. 2

Safety evaluation. The incidence of adverse events within 1 month after each dose of COVID-19 vaccine (a) and the proportion of each adverse event to the overall in two groups within 1 month after the first dose (b), the second dose (c), and the booster (d). Changes in the biochemical indices in two groups at baseline and the 1st, 2nd, 4th, 7th, 8th, 10th, and 13th months (data of the 16th month was not detected due to the pandemic interference) shown in e–n. *P < 0.05; ns no significance; GGT γ-glutamyl transpeptidase; ALP alkaline phosphatase. Other adverse events included rash, cough, pharyngeal malaise, tinnitus, and insomnia