Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

Fig. 7

Amino acid metabolism in cancer metastasis. Metabolic rewiring: Illustrates the critical role of amino acid metabolism reprogramming in supporting tumor growth, immune evasion, and metastatic spread. Arginine metabolism: Highlights the influence of VIPR1 activation and FOXO3a-regulated metabolic plasticity on HCC and ESCC progression, with a focus on ASS1 and ASL enzymes. Glutamine and Serine metabolism: Shows the impact of GOT2 downregulation and ZEB1-mediated SSP reprogramming on HCC, and the role of ANGPTL4 in NSCLC metastasis. Asparagine metabolism: Depicts the effects of targeting glutamine metabolism in PDAC and the significance of ASNS in various cancers, emphasizing its role in tumor cell proliferation and metastasis. Created with BioRender.com

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