Fig. 2
From: Current advance of nanotechnology in diagnosis and treatment for malignant tumors

The proposed strategy aims to counteract the effects of chemotherapy drugs, specifically the induction of Xkr8 and the resulting immunosuppression. This reversal strategy involves delivering siXkr8 directly to the affected site, simultaneously with the chemotherapy drugs. This approach not only targets the specific gene responsible for these effects but also utilizes the synergy between siXkr8 and the chemotherapy drugs to achieve a more effective therapeutic outcome. (Created with BioRender.com) Reproduced with permission from Chen et al.681, Copyright 2022 Springer Nature Limited