Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Redox regulation: mechanisms, biology and therapeutic targets in diseases

Fig. 2

Redox signaling regulates DNA repair. In the DNA double-strand break process, the essential sensor ATM can be oxidized at the C-terminal kinase domain (Cys2991). In HR, RPA, XRCC3, and RAD51 can be oxidized at the indicated cysteines. In NHEJ, KU70/80 and DNA-PKcs can be oxidized and regulated. In BER process, AAG, OGG1, APE1, PARP, and XRCC1 can be oxidized at the specific cysteines

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