Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Redox regulation: mechanisms, biology and therapeutic targets in diseases

Fig. 3

Epigenetic modifications are regulated by redox signaling. In the regulation of DNA and histone methylation, redox signaling can regulate the biosynthesis of SAM by oxidizing MAT. ROS can inhibit the enzyme activity of JmjC and TETs, thus regulating histone and DNA methylation. Additionally, redox signaling directly oxidizes DnaJb5 and HDACs to regulate histone acetylation

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