Fig. 1
From: Protecting cell cycle integrity: enhanced start-codon stringency in mitosis
A nuclear reservoir of eIF1 enhances translation initiation stringency during mitosis. In interphase, eIF1 is sequestered in the nucleus, limiting its availability for ribosomal association. This sequestering allows more frequent interactions between ribosomes and eIF5, which facilitates translation initiation at alternative start-codons. Upon nuclear envelope breakdown during mitosis, eIF1 is released into the cytoplasm, where it associates with ribosomes, increasing the proportion of ribosomes that initiate translation at the canonical AUG start-codon, thereby enhancing translation initiation stringency. The figure was created in BioRender. Omrani, O. (2025) https://BioRender.com/f64o283
