Table 2 Subsequent anti-tumor therapy after study treatment discontinuation

From: ACE-Breast-02: a randomized phase III trial of ARX788 versus lapatinib plus capecitabine for HER2-positive advanced breast cancer

 

ARX788 (n = 221)*

LC (n = 220)*

Any

104 (47.1)

140 (63.6)

Radiotherapy

10 (4.5)

16 (7.3)

Operation

1 (0.5)

2 (0.9)

Drug therapy

99 (44.8)

131 (59.5)

 Chemotherapy

89 (40.3)

95 (43.2)

 Targeted agents

93 (42.1)

122 (55.5)

  Anti-HER2 monoclonal antibody

31 (14.0)

60 (27.3)

  Anti-HER2 ADC

3 (1.4)

44 (20.0)

  Anti-HER2 TKI

84 (38.0)

59 (26.8)

  Others

9 (4.1)

10 (4.5)

   Anti-CDK4/6 agents

4 (1.8)

3 (1.4)

   Anti-VEGF agents

2 (0.9)

4 (1.8)

   Anti-mTOR agents

1 (0.5)

0 (0.0)

   Anti-PARP agents

0 (0.0)

1 (0.5)

   Anti-HER2/CD3 agents

1 (0.5)

1 (0.5)

   Anti FR/TRPV6 agents

1 (0.5)

1 (0.5)

   Others

1 (0.5)

0 (0.0)

 Immunotherapy

0 (0.0)

4 (1.8)

 Hormone therapy

9 (4.1)

6 (2.7)

 Other systemic therapy

4 (1.8)

7 (3.2)

  1. Data are the n (%)
  2. * ARX788 and LC groups had 71 (32.1%) and 39 (17.7%) patients receiving study assigned treatments at the data cutoff, respectively
  3. LC lapatinib plus capecitabine, HER2 human epidermal growth factor receptor 2, ADC antibody-drug conjugate, TKI tyrosine kinase inhibitor, CDK4/6 cyclin-dependent kinase 4/6, VEGF vascular endothelial growth factor, mTOR mammalian target of rapamycin, PARP poly ADP-ribose polymerase, FR folate receptor, TRPV6 Transient Receptor Potential Channel Subfamily V Member 6