Table 2 BCL2 protein targeting PROTACs and SNIPERs
From: The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy
Name | Target | Clinical | Warhead | E3 ligase | Original Ref |
|---|---|---|---|---|---|
DT2216 | BCL-XL | Yes | ABT-263 | VHL | |
XZ739 | BCL2 (inh), BCL-XL | No | ABT-263 | CRBN | |
SIAIS361034 | BCL2 (inh), BCL-XL | No | ABT-263 | CRBN | |
PZ15227 | BCL-XL | No | ABT-263 | CRBN | |
XZ424 | BCL-XL | No | A1155463 | CRBN | |
PZ703b | BCL2 (inh), BCL-XL | No | ABT-263 | VHL | |
753B | BCL2/BCL-XL | No | ABT-263 | VHL | |
WH244 | BCL2/BCL-XL | No | ABT-263 | VHL | |
C3 | MCL1 | No | Nap-1 | CRBN | |
C5 | BCL2/MCL1 | No | Nap-1 | CRBN | |
PROTAC-8a | BCL-XL | No | ABT-263 | IAPs | |
NXD02 | BCL-XL | No | Modified | VHL |
