Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

Fig. 2

Kinase classification map. Based on the similarity of kinase domain sequences, 518 human protein kinases were divided into nine groups: tyrosine kinase group (TK group), tyrosine kinase-like group (TKL group), homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases group (STE group), containing PKA, PKG, PKC families group (AGC group), calcium/calmodulin-dependent protein kinase group (CAMK group), containing CDK, MAPK, GSK3, CLK families group (CMGC group), casein kinase 1 group (CK1 group), other group, atypical protein kinase group. Proteins of pathological significance for neurodegenerative diseases were highlighted in the figure using different colors as indicated in the figure. Figures generated using KinMap (http://kinhub.org/kinmap/index.html), and illustrations reproduced courtesy of Cell Signaling Technology, Inc. (www.cellsignal.com)

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