Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir

Fig. 3

ODE-(S)-HPMPA formate and HDP-(S)-HPMPA formate showed superior therapeutic efficacies against lethal Tiantan vaccinia infection in mice. a The schematic illustration of experimental design. b Weight loss and survival rates of mice after being intranasally infected with the vaccinia Tiantan strain. Mice received the solvent served as the non-treated control. Weight loss ≥30% of initial body weight was recorded as ethical death and was therefore not represented in the figure. The data of weight loss are presented as mean ± SD. Statistical significance is indicated as follows: *, $, #: p < 0.05; **, $$, ##: p < 0.01; ***, $$$, ###: p < 0.001; ****, $$$$, ####: p < 0.0001

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