Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Fig. 4

NKG2A knockout reinvigorated NK cells from exhaustion. a CD107a, perforin, GZMB, IFN-γ, Ki67, TNF-α, T-bet, and Eomes expression in NKG2A knockout and wild-type NK92 cells after stimulation with THP-1 cells. b The T-bet, GZMB, IFN-γ and Ki-67 expression on NKG2A knockout primary NK cells stimulation with THP-1 for 5days (N = 3). c The AML derived NKG2A-knockout NK cells were stimulated with THP-1 and AML blast cells for 6 h to detect the cytotoxicity function under 5:1 (left) or 10:1 (right) E:T ratio. d The apoptosis rate of THP-1 cells or AML blast cells induced by AML-NK cells and NKG2A KO NK cells. e The schematic diagram generated from online tools bioRender, the AML mice models infusion with AML derived NKG2A KO cells or AML derived wild type NK cells (N = 5). f The total tumor flux of AML mice model at day 23 post THP-1 cells infusion between NK and NKG2A KO groups (N = 5). g Survival curve of THP-1 with PBS, THP-1 with NK cells infusion and THP-1 with NKG2A-KO NK cells groups (N = 5)

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