Fig. 2

Global CD38 deficiency inhibited oxidative stress and inflammation during HIRI. a Representative DHE staining images were taken from CD38^KO and CD38^fl/fl mice subjected to HIRI, respectively. b MDA contents were quantitatively measured in liver tissues from CD38^KO and CD38^fl/fl mice after I/R injury. c Serum TNF-α and IL-1β were detected by Elisa in CD38^KO and CD38^fl/fl mice after HIRI. d The protein expressions and the quantitative analysis of NOX2 and SOD2 were determined by western blot in liver tissues from CD38^KO and CD38^fl/fl mice after HIRI. e The mRNA expressions of TNF-α, IL1B, TGF-β, CD206, and PPARγ were determined by QPCR in CD38^KO and CD38^fl/fl mice after HIRI, respectively. f, g The expressions and the quantitative analysis of IL-1β and PPARγ were detected by Western blot in liver tissues in CD38^KO and CD38^fl/fl mice after HIRI, respectively. Data are shown as means ± SEM, *p < 0.05, **p < 0.01 and ***p < 0.001, n = 3–8 per group