Fig. 2
From: Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance
Hallmarks of cancer regulated by epigenetics. It illustrates the impact of epigenetic mechanisms on the hallmarks of cancer. The epigenetic elements are presented sequentially in the order of chromosome, DNA, and RNA, with a concise description of their functions and regulatory roles. Furthermore, the figure emphasizes the principal hallmarks influenced by epigenetic modifications, specifically highlighting the dysregulation of tumor suppressors and oncogenes, the promotion of unlimited cell proliferation and resistance to apoptosis, microenvironmental remodeling, and metabolic reprogramming, which are mentioned in the review. DNMT DNA methyltransferase, TET ten-eleven translocation, HDAC histone deacetylase, KDM lysine demethylase, KMT lysine methyltransferase, KAT lysine acetyltransferase, MBD methyl-CpG binding domain
