Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumab

Fig. 4

Regorafenib and avelumab treatment induce B and T cells infiltration in sarcoma patients. a Illustration of 7-plex immunohistofluorescence panel. b Boxplot representations of CD8+, CD4+, CD20+ (B cells) and CD163+ (M2 macrophages) cell densities. c Illustration of treatment-induced immune infiltration in one sarcoma patient with progressive disease. d Quantification of the percentage of CD20+ cells colocalized with CD3+ cells (CD4+ or CD8+) in a radius of 10 µm. e Illustration of PD-1 expression upon treatment. f Boxplot representations of PD-1 expression in CD8+ and CD4+ T cells. All the p values were calculated using Wilcoxon tests

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