Table 3 Treatment-related adverse events in 30 patients

From: Tislelizumab (anti-PD-1) plus chemotherapy as neoadjuvant therapy for patients with stage IB3/IIA2 cervical cancer (NATIC): a prospective, single-arm, phase II study

 

Any grade

Grade 1–2

Grade 3

Any treatment-related AEs

30 (100.0%)

30 (100.0%)

8 (26.7%)

 Lymphopenia

27 (90.0%)

23 (76.7%)

4 (13.3%)

 Anaemia

21 (70.0%)

21 (70.0%)

0

 Hypoproteinemia

21 (70.0%)

21 (70.0%)

0

 Leukopenia

16 (53.3%)

16 (53.3%)

0

 Neutropenia

13 (43.3%)

12 (40.0%)

1 (3.3%)

 Elevated AST

10 (33.3%)

9 (30.0%)

1 (3.3%)

 Elevated ALT

8 (26.7%)

6 (20.0%)

2 (6.7%)

 Thrombocytopenia

7 (23.3%)

6 (20.0%)

1 (3.3%)

 Rash

6 (20.0%)

6 (20.0%)

0

 Pain

5 (16.7%)

5 (16.7%)

0

 Nausea

5 (16.7%)

5 (16.7%)

0

 Loss of appetite

5 (16.7%)

5 (16.7%)

0

 Abnormal feeling

4 (13.3%)

4 (13.3%)

0

 Itching

4 (13.3%)

4 (13.3%)

0

 Vomit

4 (13.3%)

4 (13.3%)

0

 Lower extremity venous thrombosis

1 (3.3%)

1 (3.3%)

0

Immune-related AEs

7 (23.3%)

7 (23.3%)

1 (3.3%)

 Hypothyroidism

5 (16.7%)

5 (16.7%)

0

 Guillain⁃Barré syndrome

1 (3.3%)

0

1 (3.3%)

 Hyperglycemia

3 (10.0%)

3 (10.0%)

0

  1. Data are n (%). AST Aspartate Aminotransferase, ALT Alanine Aminotransferase, AEs adverse event