Table 1 IC50 values and fold increase in drug resistance of parental vs. drug-resistant cells
Drugs | Huh-7 P | Huh-7 LR | Huh-7 SR | ||
|---|---|---|---|---|---|
IC50 (μM) | IC50 (μM) | Resistant Index | IC50 (μM) | Resistant Index | |
Lenvatinib | 13.02 ± 0.73 | 50.61 ± 4.62 | 3.89 ± 0.42 | 33.52 ± 2.10 | 2.57 ± 0.22 |
Sorafenib | 6.78 ± 0.13 | 21.06 ± 0.66 | 3.11 ± 0.11 | 16.70 ± 1.15 | 2.46 ± 0.18 |
Regorafenib | 6.40 ± 0.24 | 8.53 ± 0.59 | 1.33 ± 0.11 | 10.31 ± 0.40 | 1.61 ± 0.09 |
Gefitinib | 13.78 ± 0.55 | 25.37 ± 2.70 | 1.84 ± 0.21 | 22.43 ± 1.37 | 1.63 ± 0.12 |
Lapatinib | 14.13 ± 0.51 | 18.78 ± 0.75 | 1.32 ± 0.07 | 25.47 ± 1.15 | 1.80 ± 0.09 |
5-Fluorouracil | 25.19 ± 1.64 | 42.74 ± 3.58 | 1.70 ± 0.18 | 37.31 ± 2.61 | 1.48 ± 0.13 |
Irinotecan | 24.54 ± 1.44 | 22.00 ± 1.43 | 0.90 ± 0.08 | 40.76 ± 3.72 | 1.66 ± 0.18 |
Oxaliplatin | 39.98 ± 1.60 | 59.25 ± 4.59 | 1.48 ± 0.13 | 79.75 ± 4.39 | 1.99 ± 0.12 |