Fig. 3
Epigenetic regulation of CSC-related oncogenesis and tumor progression. DNA methylation, histone methylation, histone acetylation, and histone ubiquitination regulate a number of genetic programs that sustain the tumor-forming and repopulating capacities of cancer stem cells (CSCs), including programs that: (1) enable and preserve self-renewal, (2) prevent cellular differentiation, (3) activate oncogenic signaling and/or inactivate cancer cell-intrinsic oncosuppression, (4) deregulate cell cycle control and apoptotic cell death, and (5) promote local invasiveness and metastatic dissemination. This figure summarizes findings from tumors with a recognized CSC-driven cellular hierarchy, including acute and chronic myeloid leukemia, glioblastoma, colorectal carcinoma, and breast cancer
